My clickonce app fails when the install button on the publish.htm page is
clicked.
User is prompted with a "Cannot Start Application" dialog.
Details provided from the dialog are:

PLATFORM VERSION INFO
    Windows             : 5.1.2600.196608 (Win32NT)
    Common Language Runtime     : 2.0.50727.3053
    System.Deployment.dll         : 2.0.50727.3053 (netfxsp.050727-3000)
    mscorwks.dll             : 2.0.50727.3053 (netfxsp.050727-3000)
    dfdll.dll             : 2.0.50727.3053 (netfxsp.050727-3000)
    dfshim.dll             : 2.0.50727.3053 (netfxsp.050727-3000)

SOURCES
    Deployment url            :
file:///C:/TFS%20Projects/Temp/PublishTests/WindowsFormsApplication1.application

ERROR SUMMARY
    Below is a summary of the errors, details of these errors are listed later
in the log.
    * Activation of
file:///C:/TFS%20Projects/Temp/PublishTests/WindowsFormsApplication1.application resulted in exception. Following failure messages were detected:
        + Your Web browser settings do not allow you to run unsigned applications.

COMPONENT STORE TRANSACTION FAILURE SUMMARY
    No transaction error was detected.

WARNINGS
    There were no warnings during this operation.

OPERATION PROGRESS STATUS
    * [10/2/2008 1:23:12 PM] : Activation of
file:///C:/TFS%20Projects/Temp/PublishTests/WindowsFormsApplication1.application has started.

ERROR DETAILS
    Following errors were detected during this operation.
    * [10/2/2008 1:23:12 PM]
System.Deployment.Application.InvalidDeploymentException (Manifest)
        - Your Web browser settings do not allow you to run unsigned applications.
        - Source: System.Deployment
        - Stack trace:
            at
System.Deployment.Application.ApplicationActivator.BrowserSettings.Validate(String manifestPath)
            at
System.Deployment.Application.ApplicationActivator.PerformDeploymentActivation(Uri
activationUri, Boolean isShortcut, String textualSubId, String
deploymentProviderUrlFromExtension, BrowserSettings browserSettings, String&
errorPageUrl)
            at
System.Deployment.Application.ApplicationActivator.ActivateDeploymentWorker(Object state)

COMPONENT STORE TRANSACTION DETAILS
    No transaction information is available.


Project built on Windows Xp sp3 using Visual Studio 2008 sp1 and .Net
framework 3.5 sp1.

Install is targeting same machine.

Launching windowsFormsApplication.application directly works without error.

Oops, I forgot to staet the obvious! The signing properties page DOES have a
valid cerificate, been using it for years, and "Sign the Clickonce manifests"
IS checked.

Security settings are ENABLED and requested to run as a "FULL TRUST"
application.

Here is my .application manifest:
<?xml version="1.0" encoding="utf-8"?>
<asmv1:assembly xsi:schemaLocation="urn:schemas-microsoft-com:asm.v1
assembly.adaptive.xsd" manifestVersion="1.0"
xmlns:asmv3="urn:schemas-microsoft-com:asm.v3"
xmlns:dsig="http://www.w3.org/2000/09/xmldsig#"
xmlns="urn:schemas-microsoft-com:asm.v2"
xmlns:asmv1="urn:schemas-microsoft-com:asm.v1"
xmlns:asmv2="urn:schemas-microsoft-com:asm.v2"
xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
xmlns:co.v1="urn:schemas-microsoft-com:clickonce.v1">
  <asmv1:assemblyIdentity name="WindowsFormsApplication1.exe"
version="1.0.0.9" publicKeyToken="dde2dc24be40f2e9" language="neutral"
processorArchitecture="msil" type="win32" />
  <application />
  <entryPoint>
    <assemblyIdentity name="WindowsFormsApplication1" version="1.0.0.0"
publicKeyToken="DDE2DC24BE40F2E9" language="neutral"
processorArchitecture="msil" />
    <commandLine file="WindowsFormsApplication1.exe" parameters="" />
  </entryPoint>
  <trustInfo>
    <security>
      <applicationRequestMinimum>
        <PermissionSet Unrestricted="true" ID="Custom" SameSite="site" />
        <defaultAssemblyRequest permissionSetReference="Custom" />
      </applicationRequestMinimum>
      <requestedPrivileges xmlns="urn:schemas-microsoft-com:asm.v3">
        <!--
          UAC Manifest Options
          If you want to change the Windows User Account Control level
replace the
          requestedExecutionLevel node with one of the following.

        <requestedExecutionLevel  level="asInvoker" uiAccess="false" />
        <requestedExecutionLevel  level="requireAdministrator"
uiAccess="false" />
        <requestedExecutionLevel  level="highestAvailable" uiAccess="false" />

         If you want to utilize File and Registry Virtualization for backward
         compatibility then delete the requestedExecutionLevel node.
    -->
        <requestedExecutionLevel level="asInvoker" uiAccess="false" />
      </requestedPrivileges>
    </security>
  </trustInfo>
  <dependency>
    <dependentOS>
      <osVersionInfo>
        <os majorVersion="5" minorVersion="1" buildNumber="2600"
servicePackMajor="0" />
      </osVersionInfo>
    </dependentOS>
  </dependency>
  <dependency>
    <dependentAssembly dependencyType="preRequisite"
allowDelayedBinding="true">
      <assemblyIdentity name="Microsoft.Windows.CommonLanguageRuntime"
version="2.0.50727.0" />
    </dependentAssembly>
  </dependency>
  <dependency>
    <dependentAssembly dependencyType="preRequisite"
allowDelayedBinding="true">
      <assemblyIdentity name="System.Core" version="3.5.0.0"
publicKeyToken="b77a5c561934e089" language="neutral"
processorArchitecture="msil" />
    </dependentAssembly>
  </dependency>
  <dependency>
    <dependentAssembly dependencyType="preRequisite"
allowDelayedBinding="true">
      <assemblyIdentity name="WindowsBase" version="3.0.0.0"
publicKeyToken="31bf3856ad364e35" language="neutral"
processorArchitecture="msil" />
    </dependentAssembly>
  </dependency>
  <dependency>
    <dependentAssembly dependencyType="install" allowDelayedBinding="true"
codebase="WindowsFormsApplication1.exe" size="6656">
      <assemblyIdentity name="WindowsFormsApplication1" version="1.0.0.0"
publicKeyToken="DDE2DC24BE40F2E9" language="neutral"
processorArchitecture="msil" />
      <hash>
        <dsig:Transforms>
          <dsig:Transform
Algorithm="urn:schemas-microsoft-com:HashTransforms.Identity" />
        </dsig:Transforms>
        <dsig:DigestMethod
Algorithm="http://www.w3.org/2000/09/xmldsig#sha1" />
        <dsig:DigestValue>T31C/y6TPjKvlJJ8DKv2qi3M43c=</dsig:DigestValue>
      </hash>
    </dependentAssembly>
  </dependency>
<publisherIdentity name="CN=Whelen Engineering"
issuerKeyHash="8a2ccb35ddff830b9a56d47f26af8bb5cc63fb0d" /><Signature
Id="StrongNameSignature"
xmlns="http://www.w3.org/2000/09/xmldsig#"><SignedInfo><CanonicalizationMethod
Algorithm="http://www.w3.org/2001/10/xml-exc-c14n#" /><SignatureMethod
Algorithm="http://www.w3.org/2000/09/xmldsig#rsa-sha1" /><Reference
URI=""><Transforms><Transform
Algorithm="http://www.w3.org/2000/09/xmldsig#enveloped-signature"
/><Transform Algorithm="http://www.w3.org/2001/10/xml-exc-c14n#"
/></Transforms><DigestMethod
Algorithm="http://www.w3.org/2000/09/xmldsig#sha1"
/><DigestValue>NBu/1IciCV6iV/5smxfu3vb4I0o=</DigestValue></Reference></SignedInfo><SignatureValue>Zxa9NffPOdtSsaQKr4gsEdwnc4W2p53SzOle35xrO3xWCs8PLYhhHJrLEtchJQqrQLA/jhNBwZLn7sw386C4sA==</SignatureValue><KeyInfo
Id="StrongNameKeyInfo"><KeyValue><RSAKeyValue><Modulus>6Y+CLWARcbrkTDBWucaXxWskWxgrdVjwOfllJNRm6IQUiWmvOatqEvDKPQaGCVBW4yl2cILJEa2Pcra/XNsBjQ==</Modulus><Exponent>AQAB</Exponent></RSAKeyValue></KeyValue><msrel:RelData
xmlns:msrel="http://schemas.microsoft.com/windows/rel/2005/reldata"><r:license
xmlns:r="urn:mpeg:mpeg21:2003:01-REL-R-NS"
xmlns:as="http://schemas.microsoft.com/windows/pki/2005/Authenticode"><r:grant><as:ManifestInformation
Hash="4a23f8f6deee179b6cfe57a25e092287d4bf1b34" Description=""
Url=""><as:assemblyIdentity name="WindowsFormsApplication1.exe"
version="1.0.0.9" publicKeyToken="dde2dc24be40f2e9" language="neutral"
processorArchitecture="msil" type="win32"
/></as:ManifestInformation><as:SignedBy
/><as:AuthenticodePublisher><as:X509SubjectName>CN=Whelen
Engineering</as:X509SubjectName></as:AuthenticodePublisher></r:grant><r:issuer><Signature
Id="AuthenticodeSignature"
xmlns="http://www.w3.org/2000/09/xmldsig#"><SignedInfo><CanonicalizationMethod
Algorithm="http://www.w3.org/2001/10/xml-exc-c14n#" /><SignatureMethod
Algorithm="http://www.w3.org/2000/09/xmldsig#rsa-sha1" /><Reference
URI=""><Transforms><Transform
Algorithm="http://www.w3.org/2000/09/xmldsig#enveloped-signature"
/><Transform Algorithm="http://www.w3.org/2001/10/xml-exc-c14n#"
/></Transforms><DigestMethod
Algorithm="http://www.w3.org/2000/09/xmldsig#sha1"
/><DigestValue>/cMfGBJMfAd8Wn9yMFDPf7ITIC4=</DigestValue></Reference></SignedInfo><SignatureValue>huaymcM2CQckH4X/bEvgSZi40LpBsHOJ1jr5j2zD4B7vIBnVOtPDBPFP1MltoG1lI7E7oE0dBegev0gJ253uWw==</SignatureValue><KeyInfo><KeyValue><RSAKeyValue><Modulus>6Y+CLWARcbrkTDBWucaXxWskWxgrdVjwOfllJNRm6IQUiWmvOatqEvDKPQaGCVBW4yl2cILJEa2Pcra/XNsBjQ==</Modulus><Exponent>AQAB</Exponent></RSAKeyValue></KeyValue><X509Data><X509Certificate>MIIBLzCB3qADAgECAhBm2SP6hrHdq0xaNOjBCgatMAkGBSsOAwIdBQAwHTEbMBkGA1UEAxMSV2hlbGVuIEVuZ2luZWVyaW5nMB4XDTA3MDcxMjIwMjExNFoXDTEyMDcxMjIwMjExNFowHTEbMBkGA1UEAxMSV2hlbGVuIEVuZ2luZWVyaW5nMFwwDQYJKoZIhvcNAQEBBQADSwAwSAJBAOmPgi1gEXG65EwwVrnGl8VrJFsYK3VY8Dn5ZSTUZuiEFIlprzmrahLwyj0GhglQVuMpdnCCyRGtj3K2v1zbAY0CAwEAATAJBgUrDgMCHQUAA0EAc0yQqrTQcIjqrVWaAx7l2n4CKVvBOAQqWgszeoZz2LL0taY/QxVmfbW04LUD0OWjUURL3KiuYLeRrBZY7NnNsg==</X509Certificate></X509Data></KeyInfo></Signature></r:issuer></r:license></msrel:RelData></KeyInfo></Signature></asmv1:assembly>

Thanks!

<?xml version="1.0" encoding="utf-8"?>
<asmv1:assembly xsi:schemaLocation="urn:schemas-microsoft-com:asm.v1
assembly.adaptive.xsd" manifestVersion="1.0"
xmlns:asmv3="urn:schemas-microsoft-com:asm.v3"
xmlns:dsig="http://www.w3.org/2000/09/xmldsig#"
xmlns:co.v1="urn:schemas-microsoft-com:clickonce.v1"
xmlns="urn:schemas-microsoft-com:asm.v2"
xmlns:asmv1="urn:schemas-microsoft-com:asm.v1"
xmlns:asmv2="urn:schemas-microsoft-com:asm.v2"
xmlns:xrml="urn:mpeg:mpeg21:2003:01-REL-R-NS"
xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <assemblyIdentity name="WindowsFormsApplication1.application"
version="1.0.0.9" publicKeyToken="dde2dc24be40f2e9" language="neutral"
processorArchitecture="msil" xmlns="urn:schemas-microsoft-com:asm.v1" />
  <description asmv2:publisher="Whelen Engineering"
asmv2:product="WindowsFormsApplication1"
xmlns="urn:schemas-microsoft-com:asm.v1" />
  <deployment install="true" mapFileExtensions="true" />
  <dependency>
    <dependentAssembly dependencyType="install" codebase="Application
Files\WindowsFormsApplication1_1_0_0_9\WindowsFormsApplication1.exe.manifest"
size="6839">
      <assemblyIdentity name="WindowsFormsApplication1.exe"
version="1.0.0.9" publicKeyToken="dde2dc24be40f2e9" language="neutral"
processorArchitecture="msil" type="win32" />
      <hash>
        <dsig:Transforms>
          <dsig:Transform
Algorithm="urn:schemas-microsoft-com:HashTransforms.Identity" />
        </dsig:Transforms>
        <dsig:DigestMethod
Algorithm="http://www.w3.org/2000/09/xmldsig#sha1" />
        <dsig:DigestValue>n3JngxH8CWUKFze9na21+wxLR+8=</dsig:DigestValue>
      </hash>
    </dependentAssembly>
  </dependency>
<publisherIdentity name="CN=Whelen Engineering"
issuerKeyHash="8a2ccb35ddff830b9a56d47f26af8bb5cc63fb0d" /><Signature
Id="StrongNameSignature"
xmlns="http://www.w3.org/2000/09/xmldsig#"><SignedInfo><CanonicalizationMethod
Algorithm="http://www.w3.org/2001/10/xml-exc-c14n#" /><SignatureMethod
Algorithm="http://www.w3.org/2000/09/xmldsig#rsa-sha1" /><Reference
URI=""><Transforms><Transform
Algorithm="http://www.w3.org/2000/09/xmldsig#enveloped-signature"
/><Transform Algorithm="http://www.w3.org/2001/10/xml-exc-c14n#"
/></Transforms><DigestMethod
Algorithm="http://www.w3.org/2000/09/xmldsig#sha1"
/><DigestValue>srgHxCkoGtI/W0xndtyR7zZrUCY=</DigestValue></Reference></SignedInfo><SignatureValue>Rg+zOFkpuYCM9dGGcNyfVDcOPKD1B7FJRjgbw65vtwiFFttVq1BDSy2vtXXjP+xerMO3BrWW+QW38TWgId86xA==</SignatureValue><KeyInfo
Id="StrongNameKeyInfo"><KeyValue><RSAKeyValue><Modulus>6Y+CLWARcbrkTDBWucaXxWskWxgrdVjwOfllJNRm6IQUiWmvOatqEvDKPQaGCVBW4yl2cILJEa2Pcra/XNsBjQ==</Modulus><Exponent>AQAB</Exponent></RSAKeyValue></KeyValue><msrel:RelData
xmlns:msrel="http://schemas.microsoft.com/windows/rel/2005/reldata"><r:license
xmlns:r="urn:mpeg:mpeg21:2003:01-REL-R-NS"
xmlns:as="http://schemas.microsoft.com/windows/pki/2005/Authenticode"><r:grant><as:ManifestInformation
Hash="26506b36ef91dc76674c5b3fd21a2829c407b8b2" Description=""
Url=""><as:assemblyIdentity name="WindowsFormsApplication1.application"
version="1.0.0.9" publicKeyToken="dde2dc24be40f2e9" language="neutral"
processorArchitecture="msil" xmlns="urn:schemas-microsoft-com:asm.v1"
/></as:ManifestInformation><as:SignedBy
/><as:AuthenticodePublisher><as:X509SubjectName>CN=Whelen
Engineering</as:X509SubjectName></as:AuthenticodePublisher></r:grant><r:issuer><Signature
Id="AuthenticodeSignature"
xmlns="http://www.w3.org/2000/09/xmldsig#"><SignedInfo><CanonicalizationMethod
Algorithm="http://www.w3.org/2001/10/xml-exc-c14n#" /><SignatureMethod
Algorithm="http://www.w3.org/2000/09/xmldsig#rsa-sha1" /><Reference
URI=""><Transforms><Transform
Algorithm="http://www.w3.org/2000/09/xmldsig#enveloped-signature"
/><Transform Algorithm="http://www.w3.org/2001/10/xml-exc-c14n#"
/></Transforms><DigestMethod
Algorithm="http://www.w3.org/2000/09/xmldsig#sha1"
/><DigestValue>xC+PWe/M5IZ6eRbruAHrmvYB+08=</DigestValue></Reference></SignedInfo><SignatureValue>xlEeWrkAtmIRTWJMRPmXYdaK7EINPUSMzBJi+KHYROLTgfhNx+JhYgR+KpRHyqmQgLAX1C+Pu222dCaBK551MA==</SignatureValue><KeyInfo><KeyValue><RSAKeyValue><Modulus>6Y+CLWARcbrkTDBWucaXxWskWxgrdVjwOfllJNRm6IQUiWmvOatqEvDKPQaGCVBW4yl2cILJEa2Pcra/XNsBjQ==</Modulus><Exponent>AQAB</Exponent></RSAKeyValue></KeyValue><X509Data><X509Certificate>MIIBLzCB3qADAgECAhBm2SP6hrHdq0xaNOjBCgatMAkGBSsOAwIdBQAwHTEbMBkGA1UEAxMSV2hlbGVuIEVuZ2luZWVyaW5nMB4XDTA3MDcxMjIwMjExNFoXDTEyMDcxMjIwMjExNFowHTEbMBkGA1UEAxMSV2hlbGVuIEVuZ2luZWVyaW5nMFwwDQYJKoZIhvcNAQEBBQADSwAwSAJBAOmPgi1gEXG65EwwVrnGl8VrJFsYK3VY8Dn5ZSTUZuiEFIlprzmrahLwyj0GhglQVuMpdnCCyRGtj3K2v1zbAY0CAwEAATAJBgUrDgMCHQUAA0EAc0yQqrTQcIjqrVWaAx7l2n4CKVvBOAQqWgszeoZz2LL0taY/QxVmfbW04LUD0OWjUURL3KiuYLeRrBZY7NnNsg==</X509Certificate></X509Data></KeyInfo></Signature></r:issuer></r:license></msrel:RelData></KeyInfo></Signature></asmv1:assembly>

and my .manifest manifest:

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does it happen on just one PC?

No, any on which I attempt to install.
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[Message not available]

[Message not available]

'InitializeCulture' is not a member of 'ASP.wescoreport_aspx'.
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